생약추출물이 초기우식법랑질의 재광화에 미치는 효과
Plant extracts increase the efficacy of fluoride dentifrices
홍석진, 박근형, 손재범,
소속 상세정보
홍석진 ( ) - 전남대학교 치과대학 예방치과학교실
박근형 ( ) - 전남대학교 농업생명과학대학 식품공학과
손재범 ( ) - 전남대학교 치과대학 예방치과학교실
KMID : 0355420030270020237
Abstract
Since plant extracts have shown antibacterial activities, we hypothesized that herbal plant extracts would further increase cariostatic efficacies of the fluoride dentifrices.
OBJECTIVE: The purposes of this study were to determine the minimum inhibitory concentration (MIC) of 9 different Korean herbal plants extracts on the S. sobrinus KCTC 3308 and the efficacy of NaF-Silica dentifrices with or without the extracts.
METHODS: The MIC of the methanol-extracts on the growth of S. sobrinus was determined. Subsurface caries lesions were prepared as previously described (Hong et al. J Dent Res. 77:843, 1998). After Vickers hardness number (VHN) were determined, the specimens were assigned to 9 test groups of 12 each by randomized blocks with VHN stratification. The specimens were tested for remineralization In vitro subsurface enamel lesion under cyclic microbial dynamic condition simulating in vivo carious formation. The statistical significance of delta VHNs was determined by Students t -test and one-way ANOVA.
RESULTS: The MIC of the Angelica gigas extract was 3 mg/ml, as same as Akebia quinata and Camellia sinensis was 4 mg/ml. However, all 9 extracts tested in the study demonstrated the synergistic cariostatic potential with known fluoride dentifrices.
CONCLUSION: The NaF-herbal extract in silica base dentifrice significantly increased the cariostatic effect of NaF-Silica base dentifrice.
키워드
농차;당귀;미생물학적 방법;생약추출물;으름덩굴;VHN;Angelica gigas;Akebia quinata;Camellia sinensis;Extracts;Microbial model
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